Quartz 4 https://notes.delalamo.xyz Last 10 notes on Quartz 4 Quartz -- quartz.jzhao.xyz Model type less important than data quantity when predicting catalytic properties of protein sequences https://notes.delalamo.xyz/notes/Model-type-less-important-than-data-quantity-when-predicting-catalytic-properties-of-protein-sequences https://notes.delalamo.xyz/notes/Model-type-less-important-than-data-quantity-when-predicting-catalytic-properties-of-protein-sequences Sun, 10 May 2026 10:41:28 GMT Cysteines are the most common conserved residue in E. coli https://notes.delalamo.xyz/notes/Cysteines-are-the-most-common-conserved-residue-in-E.-coli https://notes.delalamo.xyz/notes/Cysteines-are-the-most-common-conserved-residue-in-E.-coli Wed, 06 May 2026 14:04:27 GMT Buried CDR residue mutations have similar effects on expression in other globular proteins https://notes.delalamo.xyz/notes/Buried-CDR-residue-mutations-have-similar-effects-on-expression-in-other-globular-proteins https://notes.delalamo.xyz/notes/Buried-CDR-residue-mutations-have-similar-effects-on-expression-in-other-globular-proteins Wed, 06 May 2026 10:04:28 GMT CDR sequence changes are enough to destabilize antibodies https://notes.delalamo.xyz/notes/CDR-sequence-changes-are-enough-to-destabilize-antibodies https://notes.delalamo.xyz/notes/CDR-sequence-changes-are-enough-to-destabilize-antibodies Wed, 06 May 2026 10:04:28 GMT CDR1 and CDR2 contribute more to antibody stability than CDR3 https://notes.delalamo.xyz/notes/CDR1-and-CDR2-contribute-more-to-antibody-stability-than-CDR3 https://notes.delalamo.xyz/notes/CDR1-and-CDR2-contribute-more-to-antibody-stability-than-CDR3 Wed, 06 May 2026 10:04:28 GMT ESM-IF outperforms ProteinMPNN on Ab inverse folding and affinity prediction https://notes.delalamo.xyz/notes/ESM-IF-outperforms-ProteinMPNN-on-Ab-inverse-folding-and-affinity-prediction https://notes.delalamo.xyz/notes/ESM-IF-outperforms-ProteinMPNN-on-Ab-inverse-folding-and-affinity-prediction Wed, 06 May 2026 10:04:28 GMT Fold stability is more strongly correlated with a protein's ability to refold after denaturing than its melting temperature https://notes.delalamo.xyz/notes/Fold-stability-is-more-strongly-correlated-with-a-protein's-ability-to-refold-after-denaturing-than-its-melting-temperature https://notes.delalamo.xyz/notes/Fold-stability-is-more-strongly-correlated-with-a-protein's-ability-to-refold-after-denaturing-than-its-melting-temperature Wed, 06 May 2026 10:04:28 GMT Inverse folding model logits can zero-shot predict expression changes arising from in antibody CDRs in cases where ground truth structure is known https://notes.delalamo.xyz/notes/Inverse-folding-model-logits-can--zero-shot-predict-expression-changes-arising-from-in-antibody-CDRs-in-cases-where-ground-truth-structure-is-known https://notes.delalamo.xyz/notes/Inverse-folding-model-logits-can--zero-shot-predict-expression-changes-arising-from-in-antibody-CDRs-in-cases-where-ground-truth-structure-is-known Wed, 06 May 2026 10:04:28 GMT Large-scale measurements, such as Kd and IC50, from different assays correlate weakly in different studies https://notes.delalamo.xyz/notes/Large-scale-measurements,-such-as-Kd-and-IC50,-from-different-assays-correlate-weakly-in-different-studies https://notes.delalamo.xyz/notes/Large-scale-measurements,-such-as-Kd-and-IC50,-from-different-assays-correlate-weakly-in-different-studies Wed, 06 May 2026 10:04:28 GMT iPAE is anticorrelated with number of interface H-bonds https://notes.delalamo.xyz/notes/iPAE-is-anticorrelated-with-number-of-interface-H-bonds https://notes.delalamo.xyz/notes/iPAE-is-anticorrelated-with-number-of-interface-H-bonds Wed, 06 May 2026 10:04:28 GMT