Summary
Scoring functions from (Rosetta) correlate with stability, except when only energy terms between backbone atoms is considered (1). This shows that sidechain interactions are critical to accurate prediction.
1.
Ferrari ÁJR, Dixit SM, Thibeault J, Garcia M, Houliston S, Ludwig RW, et al. Large-scale discovery, analysis, and design of protein energy landscapes. openRxiv; 2025. Available from: https://doi.org/10.1101/2025.03.20.644235