Summary
AlphaFold2 models interactions between antibodies and antigens using motifs found in non-antibody structural complexes in the PDB (1). Better antibody-antigen predictions recycle interactions from non-PDB structures.
Figures
Ref (1)
See also
- Protein-protein interaction interfaces are highly degenerate
- Protein folding neural networks do not extrapolate to new ligand binding sites
1.
McCoy KM, Ackerman ME, Grigoryan G. A comparison of antibody–antigen complex sequence‐to‐structure prediction methods and their systematic biases. Protein Science. 2024;33(9). Available from: https://doi.org/10.1002/pro.5127