Summary
AlphaFold3 uses cross-distillation from AlphaFold2 to avoid modeling low-pLDDT regions that are likely disordered as helices (1). The authors claim that earlier versions of the method without this check done tended to hallucinate disordered regions as helices, despite low pLDDT.
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Ref (1)
1.
Abramson J, Adler J, Dunger J, Evans R, Green T, Pritzel A, et al. Accurate structure prediction of biomolecular interactions with AlphaFold 3. Nature. 2024;630(8016):493–500. Available from: https://doi.org/10.1038/s41586-024-07487-w