Summary
PLMs for antibodies match or slightly outperform generic PLMs on antigen specificity prediction (1). In contrast, Generic PLMs outperform antibody-specific PLMs on zero-shot predictions of affinity changes.
1.
Wang M, Patsenker J, Li H, Kluger Y, Kleinstein SH. Language model-based B cell receptor sequence embeddings can effectively encode receptor specificity. Nucleic Acids Research. 2023;52(2):548–57. Available from: https://doi.org/10.1093/nar/gkad1128