Summary
Methods that monitor changes in hydrophobicity or charge of missense mutations in antigens are better predictors of antibody escape than either metric in isolation or the BLOSUM62 matrix (1).
1.
Thadani NN, Gurev S, Notin P, Youssef N, Rollins NJ, Ritter D, et al. Learning from prepandemic data to forecast viral escape. Nature. 2023;622(7984):818–25. Available from: https://doi.org/10.1038/s41586-023-06617-0