Summary
Correct protomer structure prediction is necessary but insufficient for accurate modeling of protein quaternary structure (1). This has also been shown for CDRH3 loops in antibody-antigen complexes.
1.
Li S, Mu Z, Yan C. Dissecting the Black Box of AlphaFold in Protein–Protein Complex Assembly. openRxiv; 2026. Available from: https://doi.org/10.64898/2026.04.03.716280