Summary
Fast dynamic processes in proteins contribute to slower conformational changes (1). This was shown in the hinge region of adenylate kinase, which drives the open-closed conformational change.
1.
Henzler-Wildman KA, Lei M, Thai V, Kerns SJ, Karplus M, Kern D. A hierarchy of timescales in protein dynamics is linked to enzyme catalysis. Nature. 2007;450(7171):913–6. Available from: https://doi.org/10.1038/nature06407