Summary
Feynman-Kac steering is a sequential Monte Carlo-based scheme for guiding diffusion models at inference time. Examples include its use in the Alphafold3 clone Boltz.
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Ref (2)
1.
Hartman E, Wallin J, Malmström J, Olsson J. Controllable protein design with particle-based Feynman-Kac steering. 2025; Available from: https://arxiv.org/abs/2511.09216
2.
Rector-Brooks J, Lambert T, Skreta M, Roth D, Long Y, Li Z-Q, et al. General Multimodal Protein Design Enables DNA-Encoding of Chemistry. 2026; Available from: https://arxiv.org/abs/2604.05181