Fine-tuning AlphaFold for MHC prediction by adding Evoformer layers improves RMSD and pLDDT

Summary

AlphaFold2 can be fine-tuned on specific protein families by adding Evoformer layers (1). They added two layers and fine-tuned on MHC-I structures.

Figures

Ref (1)

1.

Glukhov E, Kalitin D, Stepanenko D, Zhu Y, Nguyen T, Jones G, et al. MHC-Fine: Fine-tuned AlphaFold for precise MHC-peptide complex prediction. Biophysical Journal. 2024;123(17):2902–9. Available from: https://doi.org/10.1016/j.bpj.2024.05.011