Summary
Gaussian processes can identify false positives. (1) found, using a Gaussian process-based model, that the GFP data in ref (2) had false positives.
1.
Tonner PD, Pressman A, Ross D. Interpretable modeling of genotype–phenotype landscapes with state-of-the-art predictive power. Proceedings of the National Academy of Sciences. 2022;119(26). Available from: https://doi.org/10.1073/pnas.2114021119
2.
Sarkisyan KS, Bolotin DA, Meer MV, Usmanova DR, Mishin AS, Sharonov GV, et al. Local fitness landscape of the green fluorescent protein. Nature. 2016;533(7603):397–401. Available from: https://doi.org/10.1038/nature17995