Summary
Hard constraints applied with guidance can be better enforced during diffusion by applying them to the fully denoised predictions and renoising them(1). In protein backbone design, this outperformed other guidance strategies reliant on intermediate predictions.
1.
Christopher JK, Seamann A, Cui J, Khare S, Fioretto F. Constrained Diffusion for Protein Design with Hard Structural Constraints. arXiv; 2025. Available from: https://arxiv.org/abs/2510.14989