Summary
High-abundance enzymes tend to be comprised of amino acids that are less costly to synthesize, particularly on the protein surface ((1) and refs 14-16 therein).
1.
Lemke O, Heineike BM, Viknander S, Cohen N, Li F, Steenwyk JL, et al. The role of metabolism in shaping enzyme structures over 400 million years. Nature. 2025;644(8075):280–9. Available from: https://doi.org/10.1038/s41586-025-09205-6