Summary
Inverse folding can generate more stable sequences when jointly run with a protein folding model (1). This was achieved using trRosetta and backpropagated trRosetta. The authors formulate this design approach by jointly considering the inverse folding model and the forward-folding model , as the former does not guarantee that the sequence preferentially folds into other states.
Figures
Ref (1)
1.
Cho Y, Dauparas J, Tsuboyama K, Rocklin G, Ovchinnikov S. Implicit modeling of the conformational landscape and sequence allows scoring and generation of stable proteins. openRxiv; 2024. Available from: https://doi.org/10.1101/2024.12.20.629706