Summary
Several reports have stated that Antibodies with kappa light chains are less hydrophobic than those with lambda light chains (references 11, 12, 17, and 18 of (1)). However, (2) found that this was not the case.
1.
Raybould MIJ, Turnbull OM, Suter A, Guloglu B, Deane CM. Contextualising the developability risk of antibodies with lambda light chains using enhanced therapeutic antibody profiling. Communications Biology. 2024;7(1). Available from: https://doi.org/10.1038/s42003-023-05744-8
2.
Shehata L, Maurer DP, Wec AZ, Lilov A, Champney E, Sun T, et al. Affinity Maturation Enhances Antibody Specificity but Compromises Conformational Stability. Cell Reports. 2019;28(13):3300-3308.e4. Available from: https://doi.org/10.1016/j.celrep.2019.08.056