Summary
The composition of lipids and/or detergents affects the conformational landscape of membrane proteins (1). This was determined using cryo-EM on MsbA, which adopts a wide inward-open conformation in detergent micelles but a narrow inward-open conformation in lipid nanodiscs.
Figures
Figures from (1)
1.
Hoffmann L, Baier A, Jorde L, Kamel M, Schäfer J-H, Schnelle K, et al. The ABC transporter MsbA in a dozen environments. Structure. 2025;33(5):916-923.e4. Available from: https://doi.org/10.1016/j.str.2025.02.002