Metal-binding enzymes are more evolutionarily constrained than non-metal-binding enzymes

Summary

Metal-binding enzymes are more evolutionarily constrained than non-metal-binding enzymes (1).

Figures

Ref (1)

1.

Lemke O, Heineike BM, Viknander S, Cohen N, Li F, Steenwyk JL, et al. The role of metabolism in shaping enzyme structures over 400 million years. Nature. 2025;644(8075):280–9. Available from: https://doi.org/10.1038/s41586-025-09205-6