Summary
Most assignments of genetic novelty are due to failure to detect homologs. This is from a study by Weisman et al; see ref (1).
See also
1.
Kilinc M, Jia K, Jernigan RL. Improved global protein homolog detection with major gains in function identification. Proceedings of the National Academy of Sciences. 2023;120(9). Available from: https://doi.org/10.1073/pnas.2211823120