Most proteins have a single folding route

Summary

Most proteins have a single folding route (1). This was determined using microsecond to millisecond long MD simulations. The exceptions were $\alpha$/$\beta$-proteins with three $\beta$-strands that folded in different orders.

See also

• High-stability substructures fold first

1.

Lindorff-Larsen K, Piana S, Dror RO, Shaw DE. How Fast-Folding Proteins Fold. Science. 2011;334(6055):517–20. Available from: https://doi.org/10.1126/science.1208351