Summary
Proteins with N- and C-termini that are close in space are correlated with correct protein folding (1). Proteins with termini far apart fold with non-two-state kinetics.
1.
Krishna MMG, Englander SW. The N-terminal to C-terminal motif in protein folding and function. Proceedings of the National Academy of Sciences. 2005;102(4):1053–8. Available from: https://doi.org/10.1073/pnas.0409114102