Summary
Natural sequences have higher pTM but lower pLDDT than de novo designed sequences (1).
Figures
Ref (1)
1.
Hayes T, Rao R, Akin H, Sofroniew NJ, Oktay D, Lin Z, et al. Simulating 500 million years of evolution with a language model. Science. 2025;387(6736):850–8. Available from: https://doi.org/10.1126/science.ads0018