No one-size-fits-all best approach to motif scaffolding protein design

Summary

There is no best-at-everything protein design method specifically for motif scaffolding (1). For some cases, hallucination outperforms diffusion, for others vice-versa. No clear pattern is evident.

Figures

Ref (1)

See also

• No one-size-fits-all best approach to zero-shot or few-shot protein fitness prediction

1.

Frank C, Khoshouei A, Fuβ L, Schiwietz D, Putz D, Weber L, et al. Scalable protein design using optimization in a relaxed sequence space. Science. 2024;386(6720):439–45. Available from: https://doi.org/10.1126/science.adq1741