Summary
The number of sequences in an MSA with ≥90% sequence identity is a better predictor of viral variant effect prediction than alignment depth (1). It is also an effective diagnostic tool to determine if the Spearman correlation to ground truth exceeds a certain threshold (0.4).
Figures
Figures from (1)
1.
Gurev S, Youssef N, Jain N, Mehrotra A, Leung SRM, Jackson A, et al. Evaluating variant effect prediction across viruses. openRxiv; 2025. Available from: https://doi.org/10.1101/2025.08.04.668549