Summary
Precision decreases and recall increases as variant effect prediction focuses on top-performing point mutations (1). In other words, most methods will correctly identify beneficial mutations, but will also predict that poor mutations are beneficial.
Figures
Ref (1)
1.
Li Z, Luo Y. Generalizable and scalable protein stability prediction with rewired protein generative models. Nature Communications. 2025;17(1). Available from: https://doi.org/10.1038/s41467-025-67609-4