Summary
Proline content correlates with high unfolding cooperativity (1). It does not correlate with overall protein stability.
Figures
Ref (1)
1.
Ferrari ÁJR, Dixit SM, Thibeault J, Garcia M, Houliston S, Ludwig RW, et al. Large-scale discovery, analysis, and design of protein energy landscapes. openRxiv; 2025. Available from: https://doi.org/10.1101/2025.03.20.644235