Summary
Changes in protein thermostability occur frequently over long evolutionary timescales, and related proteins can show drastic differences in thermostability (1).
Figures
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Ref (1)
1.
Muir DF, Asper GPR, Notin P, Posner JA, Marks DS, Keiser MJ, et al. Evolutionary-scale enzymology enables exploration of a rugged catalytic landscape. Science. 2025;388(6752). Available from: https://doi.org/10.1126/science.adu1058