Summary
Proteins with greater folding stability have more intermediate partially unfolded states (1). This was suggested by the observation that average residue-level stability () increases sublinearly relative to overall protein stability.
Figures
Ref (1)
1.
Ferrari ÁJR, Dixit SM, Thibeault J, Garcia M, Houliston S, Ludwig RW, et al. Large-scale discovery, analysis and design of protein energy landscapes. Nature. 2026;654(8120):1108–18. Available from: https://doi.org/10.1038/s41586-026-10465-z