Scrambled MSAs outperform single-sequence-prediction with AlphaFold

Summary

Scrambled MSAs outperform single sequence predictions when predicting protein structures with AlphaFold2. They perform comparably to PSSMs and much worse than intact MSAs.

Figures

Ref Sergey Ovchinnikov’s Twitter account

See also

• Protein models designed using inverse folding can be used to supplement training DBs for PLMs and structure prediction models