Summary
Deep learning-generated models of antibodies have larger hydrophobic patches than experimentally determined structures (1). This was observed with ImmuneBuilder.
Figures
Ref (1)
1.
Raybould MIJ, Marks C, Krawczyk K, Taddese B, Nowak J, Lewis AP, et al. Five computational developability guidelines for therapeutic antibody profiling. Proceedings of the National Academy of Sciences. 2019;116(10):4025–30. Available from: https://doi.org/10.1073/pnas.1810576116