Structure prediction neural networks trained on the same structural dataset are likely to predict the same conformation

Summary

Structure prediction neural networks trained on the same structural dataset are likely to predict the same conformation, even when the training hyperparameters differ This was shown by the fact that the five released Alphafold2 models all tend to model the same conformational state of fold-switching proteins (1).

Chakravarty D, Porter LL. AlphaFold2 fails to predict protein fold switching. Protein Science. 2022;31(6). Available from: https://doi.org/10.1002/pro.4353

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Structure prediction neural networks trained on the same structural dataset are likely to predict the same conformation

Summary

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