Summary
The confidence metrics from AlphaFold2 are better calibrated than those of AlphaFold3 (1). This was observed when oversampling with the two methods, the more accurate models were not given higher confidence.
Figures
Ref (1)
1.
Roney JP, Ou C, Ovchinnikov S. Protein Diffusion Models as Statistical Potentials. openRxiv; 2025. Available from: https://doi.org/10.64898/2025.12.09.693073