Summary
Protein backbone diffusion models generate more designable structures when trained on synthetic proteins compared to when trained on the PDB (1).
Figure
Ref (1)
1.
Jendrusch M, Korbel JO. Efficient protein structure generation with sparse denoising models. Nature Machine Intelligence. 2025;7(9):1429–45. Available from: https://doi.org/10.1038/s42256-025-01100-z