Summary
A subset of residue logits from ESM-IF are sufficient for accurately stability prediction (1). Correlations between perplexity and thermostability remained high when prediction inputs were limited to isoleucines and valines, hydrophobic residues, or buried residues.
Figures
Ref (1)
1.
Cagiada M, Ovchinnikov S, Lindorff‐Larsen K. Predicting absolute protein folding stability using generative models. Protein Science. 2024;34(1). Available from: https://doi.org/10.1002/pro.5233