Summary
Affinity matured antibodies can adopt binding poses that are distinct from the antibodies they evolved from (1). Anecdotally, this is quite rare.
Figures
Ref (1) — original antibody on top, affinity matured antibody on bottom
1.
Chan DTY, Jenkinson L, Haynes SW, Austin M, Diamandakis A, Burschowsky D, et al. Extensive sequence and structural evolution of Arginase 2 inhibitory antibodies enabled by an unbiased approach to affinity maturation. Proceedings of the National Academy of Sciences. 2020;117(29):16949–60. Available from: https://doi.org/10.1073/pnas.1919565117