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Recognition

Created Sep 26, 2026Modified Sep 07, 2026

Paratopes, epitopes, binding modes, cross-reactivity, and the molecular basis of antibody recognition.

39 items with this tag.

Sep 25, 2026
General-purpose language models underperform specialist models on tested epitope identification tasks
- antibodies/recognition
- evidence/generalization
Aug 25, 2026
Antibodies often target cognate ligand epitopes without reproducing ligand contacts
- antibodies/recognition
- biophysics/interactions
Aug 25, 2026
Antibody hydrophobicity sometimes correlates with polyreactivity
- design/developability
- antibodies/recognition
Aug 25, 2026
Somatic hypermutation correlates with lower polyreactivity
Aug 25, 2026
CDRH3 is necessary but insufficient to guarantee binding to a particular epitope
- antibodies/recognition
- antibodies/repertoires
Aug 19, 2026
Long CDRH3 loops are enriched in some polyreactive repertoires but are not strongly predictive alone
Aug 19, 2026
Most nanobodies do not bind using all three CDRs
- antibodies/nanobodies
- antibodies/recognition
Apr 28, 2026
Aromatic and polar residues make up disproportionate number of antigen epitopes
- antibodies/recognition
- biophysics/interactions
Apr 28, 2026
Individual antibody paratopes can recognize and bind to multiple epitopes
- antibodies/recognition
- antibodies/nanobodies
Apr 28, 2026
Subset of antigen residues contribute disproportionately to antibody binding affinity
- antibodies/recognition
- biophysics/interactions
Apr 28, 2026
Subset of mutations obtained during affinity maturation contribute disproportionately to affinity
- antibodies/maturation
- antibodies/recognition
Apr 21, 2026
Affinity maturation causes antibody-antigen interfaces to be more similar to generic PPI interfaces
Apr 21, 2026
Affinity matured antibodies can adopt distinct binding poses from germline precursors
- antibodies/maturation
- antibodies/recognition
Apr 21, 2026
Affinity-specificity tradeoff in antibodies is partially mediated by varying the magnitude of rigidification
Apr 21, 2026
Antibodies from different repertoires within a given species targeting the same epitope often have the same light chain isotype and share critical residues
Apr 21, 2026
Antibody-antigen binding modes are not necessarily defined by induced fit
- antibodies/recognition
- biophysics/dynamics
Apr 21, 2026
CDR3 far more likely to be part of paratope of nanobodies compared to antibodies
- antibodies/nanobodies
- antibodies/recognition
Apr 21, 2026
CDR3 loops encode specificity while CDR1 and CDR2 encode cross-reactivity
- antibodies/recognition
- antibodies/architecture
Apr 21, 2026
CDRH3 conformational rigidity reduces cross reactivity
Apr 21, 2026
CDRH3 has most contacts with antigen
- antibodies/recognition
- antibodies/architecture
Apr 21, 2026
Changes to hydrophobicity and charge correlate with antibody escape
- prediction/variant-effects
- antibodies/recognition
Apr 21, 2026
Conformational entropy in antibodies is inversely proportional to antigen affinity
- antibodies/recognition
- biophysics/dynamics
Apr 21, 2026
Germline precursors bind to their antigens with nanomolar affinity
- antibodies/maturation
- antibodies/recognition
Apr 21, 2026
Lower antibody affinity is desirable for minimizing on-target off-tumor binding
- cell-biology/therapeutic-mechanisms
- antibodies/recognition
Apr 21, 2026
Nanobodies and Abs target different epitopes but with similar accessibility and number of contacts
- antibodies/nanobodies
- antibodies/recognition
Apr 21, 2026
Nanobody framework residues more likely to be part of paratope than those of antibodies
- antibodies/nanobodies
- antibodies/recognition
Apr 21, 2026
Up to 22 percent of antigen binding residues are outside CDRs
- antibodies/recognition
- antibodies/architecture
Apr 21, 2026
Antibodies from naive B cells are more polyreactive
Apr 21, 2026
Broadly neutralizing antibodies
- antibodies/recognition
- antibodies/maturation
Apr 21, 2026
Complementarity-determining regions
- antibodies/architecture
- antibodies/recognition
Apr 21, 2026
GRAB motifs
- antibodies/recognition
- antibodies/repertoires
Apr 21, 2026
Individual D genes are evolutionarily selected for well-defined antigen-binding capabilities
- antibodies/repertoires
- antibodies/recognition
Apr 21, 2026
Light chain determines autospecificity
Apr 21, 2026
Most commercially available tool antibodies are nonspecific
- antibodies/recognition
- evidence/measurements
Apr 21, 2026
Net charge of CDRs strongly predicts nonspecific binding
- design/developability
- antibodies/recognition
Apr 21, 2026
Transgenic mice with only a single VH gene are nonetheless able to make effective antibodies against many targets
- antibodies/repertoires
- antibodies/recognition
Apr 21, 2026
Arginine residues in CDRH3 increases promiscuity
Apr 21, 2026
Broadly neutralizing antibodies against HIV evolve in a subset of patients
- antibodies/maturation
- antibodies/recognition
Apr 21, 2026
Multiple nanobodies can bind simultaneously
- antibodies/nanobodies
- antibodies/recognition

Created with Quartz v4.5.2 © 2026

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