Summary
AlphaFold2 outperforms ESMFold at distinguishing designable and undesignable protein backbones (1). ESMFold seems to want to fold everything, whereas AlphaFold will only fold sequences that actually fold. This is NOT true of non-beta-sheet membrane proteins (at least for AF).
Figures
Ref (1)
1.
Hermosilla AM, Berner C, Ovchinnikov S, Vorobieva AA. Validation of de novo designed water-soluble and transmembrane proteins by in silico folding and melting. openRxiv; 2023. Available from: https://doi.org/10.1101/2023.06.06.543955