Summary
Structure-based humanization is possible using models from AlphaFold2 (1). This suggests that sub-Angstrom accuracy is not necessary for that task.
1.
Tennenhouse A, Khmelnitsky L, Khalaila R, Yeshaya N, Noronha A, Lindzen M, et al. Computational optimization of antibody humanness and stability by systematic energy-based ranking. Nature Biomedical Engineering. 2023;8(1):30–44. Available from: https://doi.org/10.1038/s41551-023-01079-1