Quartz 4

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Antibodies

Created Sep 26, 2026Modified Sep 07, 2026

Computational antibody discovery, CDR design, and in-vitro or in-silico affinity optimization.

33 items with this tag.

Sep 25, 2026
Antibody-specific fine-tuning improves framework preservation and hotspot targeting in RFdiffusion
- design/antibodies
- training/fine-tuning
Aug 25, 2026
Ab-Ag inverse folding methods benefit from pretraining
Aug 25, 2026
AlphaFold3 ipTM can distinguish between antibody binders and nonbinders
Aug 25, 2026
Antibody affinity can sometimes be improved by stabilization
- design/antibodies
- biophysics/stability
Aug 25, 2026
Annealing epitope guidance reduces steric clashes in de novo antibody design
- design/antibodies
- inference/guidance
Aug 25, 2026
Computational antibody design is more reliable when HCDR3 is held fixed
- design/antibodies
- evidence/design-validation
Aug 25, 2026
Computational ranking of HCDR3 clones can underperform random selection
- evidence/design-validation
- design/antibodies
Aug 25, 2026
De novo antibody design
- design/antibodies
Aug 25, 2026
Ligand-mimicry filtering improves epitope-targeted antibody discovery
- design/antibodies
- evidence/design-validation
Jul 17, 2026
Gating template use during antibody CDR design increases success rates
- design/antibodies
May 06, 2026
ESM-IF outperforms ProteinMPNN on Ab inverse folding and affinity prediction
Apr 21, 2026
No one-size-fits-all approach to scoring antibody structures
Apr 21, 2026
Structure-based methods outperform sequence-based methods on antigen-dependent antibody design
- design/antibodies
- design/inverse-folding
Apr 21, 2026
Ab finetuning improves naturalness of inverse folding designs
Apr 21, 2026
Antibodies can be humanized using AlphaFold2 models
- design/developability
- design/antibodies
Apr 21, 2026
Antibody humanization
- design/developability
- design/antibodies
Apr 21, 2026
CUMAb
- design/developability
- design/antibodies
Apr 21, 2026
Cytokines can be added to antibody CDRs
- design/modular-proteins
- design/antibodies
Apr 21, 2026
Effectiveness of the BLOSUM62 for antibody affinity maturation varies by molecule
- design/antibodies
- design/directed-evolution
Apr 21, 2026
Heavy and light chains of de novo designed antibodies with the same framework and binding mode can be exchanged
- design/antibodies
- antibodies/architecture
Apr 21, 2026
Improvements in antigen binding are correlated with decreases in expression
- design/antibodies
- design/developability
Apr 21, 2026
Inverse folding from MD simulations
Apr 21, 2026
Inverse folding of CDRs benefits from span masking during training
Apr 21, 2026
ML optimized Ab libraries have more mutations than PSSM libraries
- design/antibodies
- design/directed-evolution
Apr 21, 2026
Nanobodies designed de novo from sequence are more flexible than either those designed from structure or those occurring in nature
Apr 21, 2026
PLM-derived antibody representations can distinguish engineered from human-derived Abs
- model-analysis/representation-geometry
- design/antibodies
Apr 21, 2026
Partial diffusion of de novo designed binders and VHHs improves refoldability and designability scores
Apr 21, 2026
Simultaneous design of scFv loops predicted to lead to more fit sequences
- design/antibodies
Apr 21, 2026
Gibbs sampling is less effective than simpler algorithms for sequence design using PSSMs
Apr 21, 2026
Hallucination of CDRs
- design/antibodies
- inference/guidance
Apr 21, 2026
Paratope losses are required to enforce CDR-mediated antigen binding during de novo antibody design by hallucination
- design/antibodies
- inference/guidance
Apr 21, 2026
Secondary structure losses are required to enforce CDR loopiness during de novo antibody design by hallucination
- design/antibodies
- inference/guidance
Apr 21, 2026
Wildtype antibody frameworks can accommodate CDRs that bind to virtually any target
- design/antibodies
- antibodies/architecture

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