Summary
Attention matrices of antibody-specific protein language models do not correspond to contacts (1). This is in contrast to generic protein language models.
Details
This was determined by fine-tuning ESM2 on paired antibody sequences from OAS.
Figures
Ref (1)
1.
Burbach SM, Briney B. Improving antibody language models with native pairing. Patterns. 2024;5(5):100967. Available from: https://doi.org/10.1016/j.patter.2024.100967