Summary
B cell proliferation during affinity maturation is driven by number of bound antigen molecules, which is in turn dictated by expression, trafficking, thermostability, and binding affinity (1).
See also
1.
Tharp CR, Catalano C, Khalifeh A, Ghaffari-Kashani S, Huang R, Kang G, et al. Biophysical trade-offs in antibody evolution are resolved by conformation-mediated epistasis. openRxiv; 2026. Available from: https://doi.org/10.64898/2026.03.12.711465