Binding affinity of protein-protein interactions correlates with buried surface area

Summary

The binding affinity between two proteins correlates with buried surface area (1). At least 500 ${\mathring{A}}^2$ are required for a stable complex to form (2), and the effect levels off at >2000 ${\mathring{A}}^2$ (1).

Figures

Ref (1); pink and black points represent protein-peptide and protein-protein interactions, respectively

1.

Chen J, Sawyer N, Regan L. Protein–protein interactions: General trends in the relationship between binding affinity and interfacial buried surface area. Protein Science. 2013;22(4):510–5. Available from: https://doi.org/10.1002/pro.2230

2.

Day ES, Cote SM, Whitty A. Binding Efficiency of Protein–Protein Complexes. Biochemistry. 2012;51(45):9124–36. Available from: https://doi.org/10.1021/bi301039t