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Protein protein interactions

Protein-protein interactions

Created Apr 10, 2026

Protein-protein interactions describe when two or more proteins bind to one another.

19 items with this tag.

May 06, 2026
iPAE is anticorrelated with number of interface H-bonds
Apr 28, 2026
Aromatic and polar residues make up disproportionate number of antigen epitopes
- protein-protein-interactions
Apr 28, 2026
Coevolutionary patterns in multiple sequence alignments do not contribute to protein-protein complex prediction
- structure-prediction/limitations
- protein-protein-interactions
Apr 28, 2026
Individual antibody paratopes can recognize and bind to multiple epitopes
- protein-protein-interactions
Apr 28, 2026
Subset of antigen residues contribute disproportionately to antibody binding affinity
- protein-protein-interactions
Apr 21, 2026
Affinity maturation causes antibody-antigen interfaces to be more similar to generic PPI interfaces
Apr 21, 2026
Agonist antibodies benefit from low affinity due to antigen clustering
Apr 21, 2026
Antibody-antigen binding modes are not necessarily defined by induced fit
- protein-protein-interactions
- antibody-antigen-interactions/misc
Apr 21, 2026
Binding affinity of protein-protein interactions correlates with buried surface area
- protein-protein-interactions
- antibody-antigen-interactions/binding-affinity
Apr 21, 2026
CDRH3 has most contacts with antigen
Apr 21, 2026
Conformational entropy in antibodies is inversely proportional to antigen affinity
Apr 21, 2026
Protein structure prediction and design confidence metrics do not correlate with binding affinity
Apr 21, 2026
Arginines have a greater propensity to form protein-protein interactions than lysines
- protein-protein-interactions
Apr 21, 2026
Monomeric AF2 is better able to distinguish positive and negative PPIs than AF2-multimer
- alphafold2
- protein-protein-interactions
Apr 21, 2026
Protein-protein interaction interfaces are highly degenerate
- protein-protein-interactions
Apr 21, 2026
Protein-protein interaction interfaces promote cotranslational assembly
- protein-protein-interactions
Apr 21, 2026
Protein-protein interfaces have looser packing than intra-chain interactions
- protein-protein-interactions
Apr 21, 2026
The Boltz-2 affinity module cannot be effectively repurposed for PPI affinity prediction
- alphafold3
- protein-protein-interactions
Apr 21, 2026
Half of pathogenic mutations in intrinsically disordered regions improve binding to partners, or create new binding partners
- protein-protein-interactions

Created with Quartz v4.5.2 © 2026

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