Biophysical models outperform linear models for stability prediction

Summary

Biophysical models outperform linear models for stability prediction and fitness prediction. Here it is considering the ddG between a folded and unfolded state; a bound state can be included when the readout is ligand binding (1)

See also

• Coupling strength of two substitutions is correlated with backbone distance

1.

Faure AJ, Martí-Aranda A, Hidalgo-Carcedo C, Beltran A, Schmiedel JM, Lehner B. The genetic architecture of protein stability. Nature. 2024;634(8035):995–1003. Available from: https://doi.org/10.1038/s41586-024-07966-0