Summary
Contrastive learning on structures of antibody Fvs leads to an ability to distinguish specific structural clusters of CDRs (1). Authors attempted to get cosine similarity to match TM-score between antibody structures. See Template CDR retrieval using embeddings.
1.
Singh R, Im C, Qiu Y, Mackness B, Gupta A, Joren T, et al. Learning the language of antibody hypervariability. Proceedings of the National Academy of Sciences. 2024;122(1). Available from: https://doi.org/10.1073/pnas.2418918121