Summary
Independent immune repertoires can converge on the same V genes when responding to a particular antigen. For example, seven of nine human anti-rabies antibodies described in a review used the VHIII family, while several mouse responses were similarly restricted to one or two VH genes (1).
See also
- Individual V, D, and J gene usage is highly uneven
- Antibodies from different repertoires within a given species targeting the same epitope often have the same light chain isotype and share critical residues
1.
Rees AR. Understanding the human antibody repertoire. mAbs. 2020;12(1). Available from: https://doi.org/10.1080/19420862.2020.1729683