Diffusion-based protein design methods undersample structural diversity in specific topologies

Summary

The diffusion-based protein backbone design method RFDiffusion undersamples backbone diversity among Rossman folds (1).

Figures

Ref (1)

See also

• Protein backbone diffusion models undersample loop-rich and alpha-beta domains and functional motifs

1.

Orr B, Crilly SE, Akpinaroglu D, Zhu E, Keiser MJ, Kortemme T. An improved model for prediction of de novo designed proteins with diverse geometries. openRxiv; 2025. Available from: https://doi.org/10.1101/2025.06.02.657515