Protein structure prediction methods predict idealized secondary structures in de novo proteins

Summary

Protein structure prediction methods predicted idealized secondary structure arrangements in de novo-designed proteins (1). This was shown with AlphaFold2, OmegaFold, RosettaFold, and others.

Figures

Ref (1)

See also

• Diffusion-based protein design methods undersample structural diversity in specific topologies

1.

Orr B, Crilly SE, Akpinaroglu D, Zhu E, Keiser MJ, Kortemme T. An improved model for prediction of de novo designed proteins with diverse geometries. openRxiv; 2025. Available from: https://doi.org/10.1101/2025.06.02.657515