Summary
Distinct fitness measurements of the same variants of the same protein can vary wildly in Spearman correlation. Rank correlations between measurements can vary widely when the same variants are evaluated under distinct definitions of fitness (1).
Figures
Ref (1)
See also
- Large-scale measurements, such as Kd and IC50, from different assays correlate weakly in different studies
- Fitness prediction
- Variant effect prediction quality correlates with DMS prediction quality
1.
Woolley PR, Feller AL, Ellington AD, Wilke CO. Overestimating zero-shot fitness prediction: Broad benchmarks mask local failures and practical limitations. openRxiv; 2026. Available from: https://doi.org/10.64898/2026.06.04.730121