Summary
Adding dropout to AlphaFold2 multimer prediction improves the recovery of Protein-protein interactions, including those involving Antibodies (1). AFSample relied on this during CASP15, beating even antibody-specific methods. They also increased recycles and sampled much more exhaustively.
1.
Wallner B. AFsample: improving multimer prediction with AlphaFold using massive sampling. Bioinformatics. 2023;39(9). Available from: https://doi.org/10.1093/bioinformatics/btad573