Summary
Trimerization domains are often used to replace the metastable membrane-spanning regions of Viral-fusion-proteins. They have other uses as well.
Examples
- Foldon: From fibritin C-terminus of bacteriophage-T4. Used in vaccines against SARS-CoV-1, SARS-CoV-2 (Spike protein), MPV, RSV
- Collagen: ??
- Aldolase: ??
- GCN4 AKA “isoleucine zipper” from yeast: Used in Hendra virus F-protein, Nipah virus F-protein, Influenza Hemagglutinin (HA)